Its name originates from Groenwijck, for "Green District." In the 20 century, Greenwich Village gained fame as an artist's haven, the bohemian capital, the cradle of the modern LGBT movement and the East Coast birthplace of the Beat Generation and the 1960s counterculture. Greenwich Village features Washington Square Park and two prestigious private colleges, New York University (NYU) and The New School. In later years, it became closely associated playwrights, actors, and musicians.

The name SoHo" originates from its location "South of Houston Street," a term coined in 1962 by urban planner Chester Rapkin, author of The South Houston Industrial Area study, known as the "Rapkin Report." The name also echoes Soho, a district in London's West End. Most of SoHo is part the SoHo–Cast Historic District, designated by the New York City Landmarks Preservation Commission in 1973, expanded in 2010, and listed on the National Register of Historic Places as a National Historic Landmark in 1978. The district covers 26 blocks and includes around 500 buildings, many featuring-iron architectural designs. Numerous side streets are paved with Belgian blocks.

The neighborhood started as farmland, later becoming a residential area in the early1 9th century. It then evolved into a merchant hub for produce, dry goods and textiles attracting artists, followed by actors, models, entrepreneurs, and other. It’s also home to the TriBeCa Film Festival which established the September 11 attacks to help revitalize the neighborhood downtown area.

One World Center, commonly referred to as One World Trade and originally named the Freedom its planning phase, serves as the centerpiece of the World Trade Center complex in Lower Manhattan, New York City.

For an unforgettable view of the Statue of Liberty and Ellis Island, The Battery (formerly known as Battery Park), located at the southern tip of Lower Manhattan, offers a vantage point to admire the New York Harbor, Governor’s Island, Brooklyn, the New Jersey Shore, and the Verrazano Bridge.

Also known as FiDi, this vibrant neighborhood at the southern tip of Manhattan. It is bordered by the West Side Highway the west, Chambers Street City Hall Park to the north, Brooklyn Bridge to the northeast, the East to the southeast, and South Ferry and the Battery to the south. Founded in 1624, modern-day New York City began in the Financial District, which overlaps with the historic New Amsterdam settlement from the late 17th century. FiDi is to the offices and headquarters of many major financial including the New York Stock Exchange the Federal Reserve Bank of New York. Anchored by Wall Street, the Financial District cements New York City's reputation as the leading financial hub and its most economically powerful city, with the New York Stock Exchange reigning as the stock exchange globally.

New York City’s Chinatown, located in Lower Manhattan, is a vibrant neighborhood bordered by the Lower East Side, Little Italy, Civic Center, and Tribeca. With a population of 90,000 to 100,000 it boasts the highest concentration of Chinese people in the Western Hemisphere. As one of the oldest Chinese ethnic enclaves, Manhattan's Chinatown is one of nine in New York City and twelve in the metropolitan area, which houses the largest ethnic Chinese population outside Asia, estimated at 893,697 as of 2017.