Largely built by the New Kingdom pharaohs Amenhotep III (1390–1352 BC) and Ramses II (1279–1213 BC), this temple is a strikingly graceful monument in the heart of the modern town. Also known as the Southern Sanctuary, its main function was during the annual Opet celebrations, when the statues of Amun, Mut and Khonsu were brought from Karnak, along the Avenue of Sphinxes, and reunited here during the inundation.

Karnak is an extraordinary complex of sanctuaries, kiosks, pylons and obelisks dedicated to the Theban triad but also to the greater glory of pharaohs. The site covers more than 2 sq km; it's large enough to contain about 10 cathedrals. At its heart is the Temple of Amun, the earthly 'home' of the local god. Built, added to, dismantled, restored, enlarged and decorated over nearly 1500 years, Karnak was the most important place of worship in Egypt during the New Kingdom. The complex is dominated by the great Temple of Amun-Ra – one of the world's largest religious complexes – with its famous hypostyle hall, a spectacular forest of giant papyrus-shaped columns. This main structure is surrounded by the houses of Amun's wife Mut and their son Khonsu, two other huge temple complexes on this site.

At the southern end of the Theban hillside, the Valley of the Queens contains at least 75 tombs that belonged to queens of the 19th and 20th dynasties as well as to other members of the royal families, including princesses and the Ramesside princes. Four of the tombs are open for viewing. The most famous of these, the tomb of Nefertari, was only reopened to the public in late 2016. The other tombs are those of Titi, Khaemwaset and Amunherkhepshef.

The west bank of luxor had been the site of royal burials since around 2100 BC, but it was the pharaohs of the New Kingdom period (1550–1069 BC) who chose this isolated valley dominated by the pyramid-shaped mountain peak of Al Qurn (The Horn). Once called the Great Necropolis of Millions of Years of Pharaoh, or the Place of Truth, the Valley of the Kings has 63 magnificent royal tombs.