Because of the religious importance and its numerous churches and monasteries, Ohrid is also famous under the name “Macedonian Jerusalem”. According the history facts, there used to be 365 churches - a church for each day! In 12th century, the city was also the seat of Archbishop of Ohrid. Since 1979 the city and the lake of Ohrid are under protection of UNESCO.

Lake Ohrid is a lake which straddles the mountainous border between the southwestern part of Macedonia and eastern Albania. It is the Europe's deepest and oldest lakes, with a unique aquatic ecosystem of worldwide importance, with more than 200 endemic species Macedonia's side of Lake Ohrid was declared a World Heritage Site by UNESCO in 1979, with the site being extended to also include the cultural and historic area of Ohrid in 1980. In 2010, NASA named one of Titan's lakes after it. In 2014, the Ohrid-Prespa Transboundary Reserve between Albania and Macedonia was added to UNESCO's World Network of Biosphere Reserves. Albania’s side of Lake Ohrid was also designated UNESCO world heritage status in 2019. North Macedonia's portion was designated as a protected Ramsar site in 2021, passing all nine criteria for proclamation. In Albania, the coastal portion of the lake holds Managed Nature Reserve status. In Macedonia, a portion of the lakeside is part of the Galičica National Park.

Remains of the Ancient theatre could be found in the heart of Ohrid old town. The Ancient theatre of Ohrid was built in 200 BC and is the only Hellenistic-type theatre in the country, as the other three in Scupi, Stobi and Heraklea Lynkestis are from Roman times. It is unclear how many people the original theater used to seat, as only the lower section still exists. The open theater has a perfect location: the two hills that surround it keep it protected from winds that could interfere with acoustics during performances.

Ohrid fortress is known as "Samuilova tvrdina" or The fortress of Tsar Samuil. it is on the highest part of the hill where Ohrid is situated. According to recent excavations by Macedonian archaeologists, it was contended that this fortress was built on the place of an earlier fortification, dated to the 4th century BC, which was probably built by King Philip II of Macedonia.

Situated on a small cliff right above the lake, this unique church is landmark of Ohrid. Saint John the Theologian, Kaneo or simply Saint John at Kaneo is a Macedonian Orthodox church overlooking Lake Ohrid. The church is dedicated to John of Patmos, the writer of Revelation, who has been by some considered to be the same person as John the Apostle. The construction date of the church remains unknown but documents detailing the church property suggest that it was built before the year 1447. Archaeologists believe that the church was constructed some time before the rise of the Ottoman Empire very likely in the 13th century.