Perge returns to history as a Pamphylian Greek city, and with Pamphylia came under successive rule by Persians, Athenians, and Persians again. Alexander the Great, after quitting Phaselis, occupied Perge with a part of his army. The road between these two towns is described as long and difficult. Alexander's rule was followed by the Diadochi empire of the Seleucids, then the Romans. Perge gained renown for the worship of Artemis, whose temple stood on a hill outside the town, and in whose honour annual festivals were celebrated.The coins of Perge represent both the goddess and her temple.

Some scholars associate the city's name with "Azatiwadaya". The known city of that name was founded by Azatiwada of Quwê on his eastern frontier, at Karatepe.[3] According to later tradition, Aspendos was founded rather earlier by Greeks who may have come from Argos. The wide range of its coinage throughout the ancient world indicates that, in the 5th century BC, Aspendos had become the most important city in Pamphylia. At that time, according to Thucydides, the Eurymedon River was navigable as far as Aspendos,[4] and the city derived great wealth from a trade in salt, oil and wool. Aspendos did not play an important role in antiquity as a political force. Its political history during the colonisation period corresponded to the currents of the Pamphylian region. Within this trend, after the colonial period, it remained for a time under Lycian hegemony. In 546 BC it came under Persian domination. The fact that the city continued to mint coins in its own name, however, indicates that