Midtown Manhattan is the central portion of the borough and serves as New York City's primary central business district. - It features iconic landmarks such as the Empire State Building, Chrysler Building, Hudson Yards Redevelopment Project, United Nations Headquarters, Grand Central Terminal, and Rockefeller Center. - Notable tourist attractions include Broadway, Times Square, and Koreatown. - Penn Station, located in Midtown, is the busiest transportation hub in the Western Hemisphere. - Midtown is among the largest central business districts globally and one of the most expensive real estate markets. - Fifth Avenue in Midtown has recorded the world's highest retail rents, averaging US$3,000 per square foot annually.

Located in Midtown Manhattan, New York City, is a Catholic cathedral and the seat of the Archbishop of New York. It occupies a full city block between 5th Avenue, Madison Avenue, 50th Street, and 51st Street, directly facing Rockefeller Center. Designed by James Renwick Jr., it is the largest Gothic Revival Catholic cathedral North America Construction began in 1858 to serve the expanding Archdiocese of New and replace St. Patrick's Old Cathedral. Work paused during the American Civil War in the early1860s but was completed in 1878 and dedicated on May 25, 1879. The archbishop's house and rectory also designed by Renwick, were added in the 1880s, and the spires followed in 1888.

The Flatiron Building, originally called the Fuller Building, is a 22-story, 285-foot-tall (86.9 m) steel-framed landmark located at 175 Fifth Avenue in Manhattan's Flatiron District. Designed by Daniel Burnham and Frederick P. Dinkelberg, it was nicknamed "Burnham's Folly" in its early days. Completed in 1902 with 20 floors, the building occupies a triangular block formed by Fifth Avenue, Broadway, and East 22nd Street, with its 87-foot (27 m) back end on East 22nd Street and East 23rd Street touching the northern peak. Its name, "Flatiron," comes from its triangular shape, resembling a cast-iron clothes iron.

The West Village attracts stylish crowds with its chic boutiques trendy eateries. Its charming streets, some still cobblestone, are lined with Federal-style townhouses sprinkled with public squares. Highlights include the Village jazz and the Stonewall Inn, famous for the 1969 riots that sparked gay rights movement. This historically artistic neighborhood boasts piano bars, cabarets, and theaters.

The name "SoHo" derives from the area being "South of Houston Street", and was coined in 1962 by Chester Rapkin, an urban planner and author of The South Houston Industrial Area study, also known as the "Rapkin Report". The name also recalls Soho, an area in London's West End. Almost all of SoHo is included in the SoHo–Cast Iron Historic District, which was designated by the New York City Landmarks Preservation Commission in 1973, extended in 2010, and was listed on the National Register of Historic Places and declared a National Historic Landmark in 1978. It consists of 26 blocks and approximately 500 buildings, many of them incorporating cast-iron architectural elements. Many side streets in the district are paved with Belgian blocks.

Manhattan's Chinatown is a neighborhood in Lower Manhattan, New York City, bordering the Lower East Side to its east, Little Italy to its north, Civic Center to its south, and Tribeca to its west. With an estimated population of 90,000 to 100,000 people, Chinatown is home to the highest concentration of Chinese people in the Western Hemisphere. Manhattan's Chinatown is also one of the oldest Chinese ethnic enclaves. The Manhattan Chinatown is one of nine Chinatown neighborhoods in New York City, as well as one of twelve in the New York metropolitan area, which contains the largest ethnic Chinese population outside of Asia, comprising an estimated 893,697 individuals as of 2017.

The National September 11 Memorial & Museum, located within the World Trade Center complex in New York City, was created to honor the victims of the September 11, 2001 attacks, which claimed 2,977 lives, and the 1993 World Trade Center bombing, which killed six.

Brookfield Place is a shopping center and office building complex in the New York City borough of Manhattan. It is located in the Battery Park City neighborhood, across West Street from the World Trade Center, and overlooks the Hudson River.

Brookfield Place is a shopping center and office building complex in the New York City borough of Manhattan. It is located in the Battery Park City neighborhood, across West Street from the World Trade Center, and overlooks the Hudson River.

Also known as FiDi, is a neighborhood located on the southern tip of Manhattan. It is bounded by the West Side Highway on the west, Chambers Street and City Hall Park on the north, Brooklyn Bridge on the northeast, the East River to the southeast, and South Ferry and the Battery on the south. New York was created in the modern-day Financial District in 1624, and the neighborhood roughly overlaps with the boundaries of the New Amsterdam settlement in the late 17th century.The district comprises the offices and headquarters of many of the city's major financial institutions, including the New York Stock Exchange and the Federal Reserve Bank of New York. Anchored on Wall Street in the Financial District, New York City has been called both the leading financial center and the most economically powerful city of the world, and the New York Stock Exchange is the world's largest stock exchange.

The Brooklyn Bridge is a hybrid cable-stayed/suspension bridge in New York City, spanning the East River between the boroughs of Manhattan and Brooklyn. Opened on May 24, 1883, the Brooklyn Bridge was the first fixed crossing of the East River. It was also the longest suspension bridge in the world at the time of its opening, with a main span of 1,595.5 feet (486.3 m) and a deck 127 ft (38.7 m) above mean high water. The span was originally called the New York and Brooklyn Bridge or the East River Bridge but was officially renamed the Brooklyn Bridge in 1915.

The neighborhood began as farmland, then was a residential neighborhood in the early 19th century, before becoming a mercantile area centered on produce, dry goods, and textiles, and then transitioning to artists and then actors, models, entrepreneurs, and other celebrities. The neighborhood is home to the TriBeCa Festival, which was created in response to the September 11 attacks, to reinvigorate the neighborhood and downtown after the destruction caused by the terrorist attacks.

DUMBO, an acronym for Down Under the Manhattan Bridge Overpass is a neighborhood in the New York City borough of Brooklyn. - A popular location for Instagram posts, and The New York Times has referred it to "the most Instagrammable neighborhood in America